Solid lipid nanoparticles: Influence of composition, fabrication methods and problems, in vitro drug release and intranasal administration provide to access olfactory bulb pathway for SLNs

Background: Solid lipid nanoparticles (SLN) have drawn increasing interest in recent years. These are formed from stable or solid mixtures and then stabilized by emulsifiers. As nanoparticles, colloidal particles running size somewhere the 10 to 1000 nm range known. SLN provides fascinating properties, such as minimal scale, massive surface area, high medication piling, correspondence of stages at interface, is interested their ability enhance drug execution. Main text: This paper a description choice ingredients, effect lipids structure on formulation, various methods processing SLN. We explain characteristics stability possibilities stabilization lyophilization this article. The relation between absorption complexity dispersions, which involves existence other structures physical state lipid, uncommonly considered. define possible problems preparation performance basis characterization. First, nasal route was known accomplish avoidance first-pass hepatic metabolism order maximize absolute bioavailability, secondly, immediate nose-to-brain pathway delivery brain medicines. SLNs been designated increase permeability through blood-brain barrier device (BBB). Conclusion: To sum up, article gives insight carrier places together compensations polymeric numerous benefits easy incorporation lipophilic well hydrophilic drugs, suitable stability, available low cost manufacture. accepted exploit first its prevention second, direct delivery. were chosen system improve across (BBB) consequently